He was aged 53.
Khan was admitted to the hospital on Tuesday with a colon infection.
In March 2018, he revealed he had been diagnosed with a neuroendocrine tumour, but after extensive treatment he recovered well enough to shoot Angrezi Medium, which would turn out to be his last, and whose release this March was cut short because of the coronavirus pandemic.
Khan who rose to popularity through his strong acting skills in Bollywood films such as Maqbool, Life in a Metro, Piku and The LunchboxKhan also maintained a parallel career in Anglo-American cinema: he played the chief of police in Michael Winterbottom’s A Mighty Heart, and another police man in the sensationally successful Slumdog Millionaire, which went on to win eight Oscars.
Later roles saw him become a reliable standby character actor in big-budget Hollywood films, playing a doctor in The Amazing Spider-Man in 2012 and businessmen in Jurassic World (2015) and Inferno (2016). In 2012 he also played the adult version of the lead character in another Oscar-winner: the Ang Lee-directed Life of Pi.