Little Richard's hits included Good Golly Miss Molly, which made the UK charts in 1958. The Beatles, Elton John and Elvis all cited him an influence.
The singer, born in Georgia as Richard Wayne Penniman, was among the first group inductees into the Rock and Roll Hall of Fame in 1986.
His other well-known songs include Tutti Frutti and Long Tall Sally.
The star, who sold more than 30 million records worldwide, was known for his exuberant performances, shrieks, raspy voice and flamboyant outfits. He had his biggest hits in the 1950s.