He told CNN he believed there would be a "significant reduction" in Covid-19 cases if every American wore a face covering.
Mr Biden also said he would order masks to be worn in all government buildings.
The US has recorded 14.1 million cases and 276,000 deaths from Covid-19 - the highest of any country in the world.
Mr Biden is preparing to take office as pharmaceutical giants are poised to ship millions of doses of coronavirus vaccines to the American public.
The UK on Wednesday became the first country in the world to approve the Pfizer vaccine.