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Nobel prize for scientists behind mRNA technology

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The Nobel Prize in Physiology or Medicine has been awarded to a pair of scientists who developed the technology that led to the mRNA Covid vaccines.

Prof Katalin Kariko and Prof Drew Weissman will share the prize.

The technology was experimental before the pandemic, but has now been given to millions of people around the world.

The same mRNA technology is now being researched for other diseases, including cancer.

The Nobel Prize Committee said: “The laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.”

Both were told they had won by telephone this morning and were said to be “overwhelmed”.

Vaccines train the immune system to recognise and fight threats such as viruses or bacteria.

Traditional vaccine technology has been based on dead or weakened versions of the original virus or bacterium – or by using fragments of the infectious agent.

In contrast, mRNA vaccines used a completely different approach.

During the Covid pandemic, the Moderna and Pfizer/BioNTech vaccines were both based on mRNA technology.

Katalin Kariko is now a professor at Szeged University in Hungary and Drew Weissman is still working as a professor at the University of Pennsylvania.

(BBC News)

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Joe Biden diagnosed with aggressive prostate cancer

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Former US President Joe Biden, 82, has been diagnosed with prostate cancer that has spread to his bones, a statement from his office said on Sunday.

Biden, who left office in January, was diagnosed on Friday after he saw a doctor last week for urinary symptoms.

The cancer is a more aggressive form of the disease, characterised by a Gleason score of 9 out of 10. This means his illness is classified as “high-grade” and the cancer cells could spread quickly, according to Cancer Research UK.

Biden and his family are said to be reviewing treatment options. His office added that the cancer was hormone-sensitive, meaning it could likely be managed.

In Sunday’s statement, Biden’s office said: “Last week, President Joe Biden was seen for a new finding of a prostate nodule after experiencing increasing urinary symptoms.

“On Friday, he was diagnosed with prostate cancer, characterised by a Gleason score of 9 (Grade Group 5) with metastasis to the bone.

“While this represents a more aggressive form of the disease, the cancer appears to be hormone-sensitive which allows for effective management.”

After news broke of his diagnosis, the former president received support from both sides of the aisle.

President Donald Trump wrote on his social media platform Truth Social that he and First Lady Melania Trump were “saddened to hear about Joe Biden’s recent medical diagnosis”.

“We extend our warmest and best wishes to Jill and the family,” he said, referring to former First Lady Jill Biden. “We wish Joe a fast and successful recovery.”

Former Vice-President Kamala Harris, who served under Biden, wrote on X that she and her husband Doug Emhoff are keeping the Biden family in their prayers.

“Joe is a fighter – and I know he will face this challenge with the same strength, resilience, and optimism that have always defined his life and leadership,” Harris said.

In a post on X, Barack Obama – who served as president from 2009 to 2017 with Joe Biden as his deputy – said that he and his wife Michelle were “thinking of the entire Biden family”.

“Nobody has done more to find breakthrough treatments for cancer in all its forms than Joe, and I am certain he will fight this challenge with his trademark resolve and grace. We pray for a fast and full recovery,” Obama said. In 2016, Obama tasked Biden with leading a “cancer moonshot” government-wide research programme.

(BBC News)

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Pakistan PM Shehbaz offers dialogue with India for ‘peace’

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The Indian Army on Thursday (May 16) said it will pursue confidence building measures to reduce the “alertness level” in line with the May 10 understanding on cessation of hostilities with the Pakistani side.

The remarks by the Indian Army came hours after Islamabad said the India-Pakistan arrangement on stopping the military actions has been extended till May 18.

Pakistan Prime Minister Shehbaz Sharif on Thursday extended an offer of talks to India, saying Pakistan is ready to engage “for peace”. Mr. Shehbaz made the comments during a visit to the Kamra air base in the country’s Punjab province where he interacted with officers and soldiers involved in the recent military confrontation with India.

“We are ready to talk with it (India) for peace,” he said and added that the “conditions for peace” include the Kashmir issue.

(The Hindu)

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Plane crash victims’ families file complaint against Jeju Air CEO

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Some families of those killed in a Jeju Air plane crash last December have filed a criminal complaint against 15 people, including South Korea’s transport minister and the airline’s CEO, for professional negligence.

The 72 bereaved relatives are calling for a more thorough investigation into the crash, which killed 179 of the 181 people on board – making it the deadliest plane crash on South Korean soil.

The crash was “not a simple accident”, they allege, but a “major civic disaster caused by negligent management of preventable risks”.

Nearly five months on, authorities are still studying what may have caused the plane to crash-land at Muan International Airport and then burst into flames.

The police had already opened a criminal investigation before this latest complaint, and barred Jeju Air CEO Kim E-bae from leaving the country, but no one has been indicted over the incident.

One of the relatives, Kim Da-hye, denounced the “lack of progress” in investigations.

“We are filled with deep anger and despair. Having taken this extraordinary measure of filing a criminal complaint, we will not give up and will continue to pursue the truth,” Mr Kim said in a statement to the media.

Among the 15 people named in the complaint were government officials, airline officials and airport staff responsible for construction, supervision, facility management and bird control.

The complaint filed on Tuesday raises questions around the circumstances of the crash, including whether air traffic control responded appropriately and whether the reinforcement of a mound at the end of the runway violated regulations.

The aircraft, a Boeing 737-800, took off from the Thai capital of Bangkok on the morning of 29 December, and was flying to Muan in South Korea.

Five minutes after the pilots made contact with Muan International Airport, they reported striking a bird and declared a mayday signal.

The pilots then tried to land from the opposite direction, during which the aircraft belly-landed without its landing gear deployed. It later overran the runway, slammed into a concrete structure and exploded.

Earlier this year, investigators said they found bird feathers in both engines of the jet, but did not conclude the extent to which the bird strike was a contributing factor.

Since the incident, some bereaved families have also been targeted by a torrent of conspiracies and malicious jokes online.

These included suggestions that families were “thrilled” to receive compensation from authorities, or that they were “fake victims”. As of March this year, eight people have been apprehended for making such derogatory and defamatory online posts.

(BBC News)

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