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WHO recommends another vaccine for malaria prevention

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The World Health Organization (WHO) has recommended a new vaccine, R21/Matrix-M, for the prevention of malaria in children.

The recommendation follows advice from the WHO: Strategic Advisory Group of Experts on Immunization (SAGE) and the Malaria Policy Advisory Group (MPAG) and was endorsed by the WHO Director-General following its regular biannual meeting held on 25-29 September.

WHO also issued recommendations on the advice of SAGE for new vaccines for dengue and meningitis, along with immunization schedule and product recommendations for COVID-19.  WHO also issued key immunization programmatic recommendations on polio, IA2030 and recovering the immunization programme.

The R21 vaccine is the second malaria vaccine recommended by WHO, following the RTS,S/AS01 vaccine, which received a WHO recommendation in 2021. Both vaccines are shown to be safe and effective in preventing malaria in children and, when implemented broadly, are expected to have high public health impact. Malaria, a mosquito-borne disease, places a particularly high burden on children in the African Region, where nearly half a million children die from the disease each year.

Demand for malaria vaccines is unprecedented; however, available supply of RTS,S is limited.  The addition of R21 to the list of WHO-recommended malaria vaccines is expected to result in sufficient vaccine supply to benefit all children living in areas where malaria is a public health risk.  

“As a malaria researcher, I used to dream of the day we would have a safe and effective vaccine against malaria. Now we have two,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “Demand for the RTS,S vaccine far exceeds supply, so this second vaccine is a vital additional tool to protect more children faster, and to bring us closer to our vision of a malaria-free future.”

Dr. Matshidiso Moeti, WHO Regional Director for Africa, emphasized the importance of this recommendation for the continent, saying: “This second vaccine holds real potential to close the huge demand-and-supply gap. Delivered to scale and rolled out widely, the two vaccines can help bolster malaria prevention and control efforts and save hundreds of thousands of young lives in Africa from this deadly disease.”

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US Supreme Court halts Trump’s deportation of Venezuelans under wartime law

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The US Supreme Court orders the Trump administration to pause the deportation of suspected Venezuelan gang members under a 18th-century wartime law.

The American Civil Liberties Union (ACLU) had sued the Trump administration over planned deportations of Venezuelans held in a detention centre in north Texas.

On Saturday, the Supreme Court ordered the government to “not remove any member of the putative class of detainees from the United States until further order of this Court”.

Justice Clarence Thomas and Justice Samuel Alito dissented.

US President Donald Trump had invoked the 1798 Alien Enemies Act and accused Venezuelan gang Tren de Aragua (TdA) of “perpetrating, attempting, and threatening an invasion or predatory incursion” on US territory.

(BBC News)

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Telescope finds promising hints of life on distant planet

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Scientists have found new but tentative evidence that a faraway world orbiting another star may be home to life.

A Cambridge team studying the atmosphere of a planet called K2-18b has detected signs of molecules which on Earth are only produced by simple organisms.

This is the second, and more promising, time chemicals associated with life have been detected in the planet’s atmosphere by Nasa’s James Webb Space Telescope (JWST).

But the team and independent astronomers stress that more data is needed to confirm these results.

The lead researcher, Prof Nikku Madhusudhan, told me at his lab at Cambridge University’s Institute of Astronomy that he hopes to obtain the clinching evidence soon.

“This is the strongest evidence yet there is possibly life out there. I can realistically say that we can confirm this signal within one to two years.”

K2-18b is two and a half times the size of Earth and is seven hundred trillion miles away from us.

JWST is so powerful that it can analyse the chemical composition of the planet’s atmosphere from the light that passes through from the small red Sun it orbits.

The Cambridge group has found that the atmosphere seems to contain the chemical signature of at least one of two molecules that are associated with life: dimethyl sulphide (DMS) and dimethyl disulphide (DMDS). On Earth, these gases are produced by marine phytoplankton and bacteria.

Prof Madhusudhan said he was surprised by how much gas was apparently detected during a single observation window.

“The amount we estimate of this gas in the atmosphere is thousands of times higher than what we have on Earth,” he said.

“So, if the association with life is real, then this planet will be teeming with life,” he told me.

Prof Madhusudhan went further: “If we confirm that there is life on k2-18b it should basically confirm that life is very common in the galaxy”.

There are lots of “ifs” and “buts” at this stage, as Prof Madhusudhan’s team freely admits.

Firstly, this latest detection is not at the standard required to claim a discovery.

For that, the researchers need to be about 99.99999% sure that their results are correct and not a fluke reading. In scientific jargon that is a five sigma result.

These latest results are only three sigma, 99.7%. Which sounds a lot, but it is not enough to convince the scientific community. But it is much more than the one sigma result of 68% the team obtained 18 months ago,, which was greeted with much scepticism at the time.

But even if the Cambridge team obtains a five sigma result, that won’t be conclusive proof that life exists on the planet, according to Prof Catherine Heymans of Edinburgh University and Scotland’s Astronomer Royal, who is independent of the research team.

“Even with that certainty, there is still the question of what is the origin of this gas,” she told BBC News.

“On Earth it is produced by microorganisms in the ocean, but even with perfect data we can’t say for sure that this is of a biological origin on an alien world because loads of strange things happen in in the Universe and we don’t know what other geological activity could be happening on this planet that might produce the molecules.”

That view is one the Cambridge team agree with; they are working with other groups to see if DMS and DMDS can be produced by non-living means in the lab.

Other research groups have put forward alternative, lifeless, explanations for the data obtained from K2-18b. There is a strong scientific debate not only about whether DMS and DMDS are present but also the planet’s composition.

The reason many researchers infer that the planet has a vast liquid ocean is the absence of the gas amonia in K2-18b’s atmosphere. Their theory is that the ammonia is absorbed by a vast body of water below . But it could equally be explained by an ocean of molten rock, which would preclude life, according to Prof Oliver Shorttle of Cambridge University.

“Everything we know about planets orbiting other stars comes from the tiny amounts of light that glance off their atmospheres. So it is an incredibly tenuous signal that we are having to read, not only for signs of life, but everything else.

“With K2-18b part of the scientific debate is still about the structure of the planet,” he said.

Dr Nicolas Wogan at Nasa’s Ames Research Center has yet another interpretation of the data. He published research suggesting that K2-18b is a mini gas giant with no surface.

Both these alternative interpretations have also been challenged by other groups on the grounds that they are inconsistent with the data from JWST, which highlights the strong scientific debate surrounding K2-18b.

Prof Madhusudhan acknowledges that there is still a scientific mountain to climb if he is to answer one of the biggest questions in science. But he believes he and his team are on the right track.

“Decades from now, we may look back at this point in time and recognise it was when the living universe came within reach,” he said.

“This could be the tipping point, where suddenly the fundamental question of whether we’re alone in the universe is one we’re capable of answering.”

The research has been published in The Astrophysical Journal Letters.

(BBC News)

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China responds to claims of 245% tariffs on imports to US

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In response to an inquiry about the White House’s statement claiming China now faces up to a 245 percent tariff on imports to the US as a result of its retaliatory actions, Chinese Foreign Ministry spokesperson Lin Jian responded on Wednesday that “you can ask the US side for the specific tax rate figures.”

Lin said on Wednesday’s press briefing that China has repeatedly stated its solemn position on the tariff issue. The tariff war was initiated by the US. China has taken necessary countermeasures to safeguard its legitimate rights and interests and international fairness and justice, which is completely reasonable and legal. Tariff and trade wars have no winner. China does not want to fight these wars but is not scared of them.

(Global Times)

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